Scientist / Senior Scientist, Drug Discovery Biology & Translational Medicine | Treeline Biosciences | Watertown, MA

About the role

We are seeking an experienced, enthusiastic and highly motivated cancer biologist to join our team. With a strong background in cell-based assay development, cell line engineering, in vivo oncology models, and a track record of contributing to multidisciplinary drug discovery teams, this position will play a critical role in advancing Treeline’s portfolio. You will collaboratively make key contributions to the validation and selection of the next generation of oncology targets using various state-of-the-art scientific approaches. Additionally, you will drive advances in technology, infrastructure, and biology to accelerate the path to medicines.

About you

You thrive in a fast-paced and matrixed discovery environment requiring scientific curiosity and rigor. With a drive to succeed, you are an innovative, detail-oriented, and a critical thinker who enjoys multidisciplinary collaborations to tackle difficult scientific challenges and move programs forward.


  • Develop and execute cell-based assay cascades to support drug discovery campaigns and mechanism of action studies.
  • Execute a wide variety of cellular and molecular techniques to validate and characterize genetic or small molecule perturbations of targets and downstream pathways.
  • Explore and guide translational paths of drug discovery programs using in vitro and in vivo oncology model systems
  • Design and conduct well controlled high-quality scientific experiments to test biological hypotheses.
  • Evaluate and develop new approaches and technologies within the biology group.
  • Maintain an electronic lab notebook in compliance with company policies.
  • Help establish the biology group and contribute to building a culture that embraces continuous learning and improvement.



  • BS or MS in Biology, Pharmacology, or related discipline with at least 8 years of industry experience, or PhD with 2+ years of postdoctoral research experience.
  • Extensive experience in mammalian cell culture, cell-based assays, mechanistic investigation using chemical and genetic tools, cell line engineering using CRISPR and RNAi.
  • Strong understanding and hands-on experience in developing and performing flow cytometry-based assays
  • Experience with general molecular biological techniques, e.g. molecular cloning, qPCR, ELISA, MSD, proximity-based assays, Western blotting, immunoprecipitation.
  • Strong understanding of cancer signaling pathways, protein homeostasis, and regulation of gene expression.
  • Strong written and oral communication skills, excellent interpersonal skills, with demonstrated ability to work collaboratively on cross-functional, multidisciplinary teams.
  • Self-motivated individual wanting to work in a fast-paced and dynamic startup environment with the ability to multitask.


  • Knowledge and hands-on experience with oncology mouse models and in vivo pharmacology
  • A track record of leading from the bench to drive hit-to-lead, and lead optimization experiments to deliver small molecule development candidates.
  • Experience managing research through CROs and external collaborators.


Interested in this job? Meet Treeline Biosciences at Biotech Networks US West Coast, Northeast and Remote Life Science Virtual Career Fair Feb 10 2022

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